Will this be EFI? Pump e85 or race e85? Is this a 6000lb truck? Or a 2600lb car? Will it be wide open throttle below peak torque RPM? Stick car? Auto?
There are so many variables and DCR is not one of them to even care about.
14:1 could be safe at say .80 lambda but disastrous at .92 lambda. Even though it might make peak power at .88.
Some things you just have to try yourself. Your 14:1 compression might actually be 12.8:1 measured.
So just because it works for someone else doesn't necessarily mean swing for the moon.
From my experience 13:1 is a good place to start for a beginner on e85 in many applications.
8 o2 sensors will help. Just like anything sneak up on it and be safe.